Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 4, Pages 590-597Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9007188
Keywords
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Funding
- National HighTech Research and Development [2006AA09Z423]
- National Natural Science Foundation of China [20502035]
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Ten new polyhydroxysteroidal glycosides, anthenosides B-K (2-11), were isolated from the ethanol extract of the starfish Antlzenea chinensis. Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The unprecedented carbohydrate chain 6-O-methyl-beta-D-galactofuranosyl-(1 -> 3)-(6-O-methyl-beta-D-galactofuranose) was present in all the compounds except compounds 10 and 11. Compounds 5, 7, a mixture of 8 and 9, and a mixture of 10 and 11 showed inhibitory activity against human tumor K-562 and BEL-7402 cells. Furthermore, the mixture of 10 and 11 also exhibited cytotoxicity against human tumor U87MG cells and promoted tubulin polymerization.
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