Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 10, Pages 1714-1717Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100337j
Keywords
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Funding
- CONICET [PEI 6478]
- UBA
- ANPCyT [PICT (2003) 14321, PICT-2007-02200, PICT-2008-1119]
- CAPES (Brazil)
- CONICET
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Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations.
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