Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 5, Pages 966-968Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9006734
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Funding
- Spanish MICIIN [CTQ2008-06806-C02-01/BQU, RTICC RD06/0020/1046]
- Canary Islands ACIISI [PI 2007/021]
- FUNCIS [REDESFAC PI 01/06, 35/06]
- Spanish MEC-FSE for a Ramon y Cajal
- Agencia Nacional de Promocion Cientifica y Tecnologica, Universidad de Buenos Aires, CONICET
- SeCyT-UNC
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The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 mu M. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
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