Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 3, Pages 422-427Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900632r
Keywords
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Funding
- Natural Sciences and Engineering Research Council of Canada
- National Cancer Institute of Canada
- Canadian Breast Cancer Foundation
- UBC University Graduate Fellowship
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Five new bafilomycins. F (1) to J (5), have been isolated from laboratory Cultures of two Streptomyces spp. obtained front marine sediments collected in British Columbia, and their Structures have been elucidated by detailed analysis of spectroscopic data and the synthesis of model compounds. The new bafilomycins F (1), G (2), H (3), and J (5) alone with several co-occurring known analogues showed potent inhibition of autophagy in microscopy and biochemical assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product.
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