Hydroxylated Sclerosporin Derivatives from the Marine-Derived Fungus Cadophora malorum

The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth Oil a biomalt medium supplemented with sea salt yielded all extract. from which We have isolated selerosporin and four new hydroxylated selerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated ill various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipoicytes.