Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 3, Pages 303-305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900694j
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Funding
- JSPS [16GS0206, 21221009]
- Grants-in-Aid for Scientific Research [16GS0206, 21221009, 22603008] Funding Source: KAKEN
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Two new members of the complanine family, neocomplanines A (2) and B (3), were isolated as minor components of the methanolic extract of the marine fireworm Eurythoe complanata. The structures of the neocomplanines were revealed spectroscopically to be a trimethylammonium unit with a saturated carbon chain. The planar structures of neocomplanines A and B were confirmed successfully through total syntheses that used epichlorohydrin as a starting material. The neocomplanines show inflammatory activity and also enhanced PKC activity in combination with TPA in the presence of Ca(2+) in vitro; both arc similar to the effects of complanine (1). The molecular mechanism of the effects of complanine-related compounds is discussed.
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