Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 4, Pages 712-715Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900526y
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Funding
- NIH [2U19-CA529955]
- NATIONAL CANCER INSTITUTE [U19CA052955] Funding Source: NIH RePORTER
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Bioactivity-guided fractionation of metabolites from the crinoid Holopus rangii led to the discovery of two new phenanthroperylenequinone derivatives, gymnochromes E (1) and F (2). Gymnochrome E showed cytotoxic activity toward the NCI/ADR-Res with an IC50 of 3.5 mu M. It also inhibited histone deacetylase-1 with an IC50 of 3.3 Gymnochrome F was a moderate inhibitor of myeloid cell leukemia sequence 1 (MCL-1) binding to Bak. Two anthraquinone metabolites, emodic acid (4) and its new bromo derivative (5), were also isolated from the crinoid and show remarkable similarity to the phenanthroperylenequinone core, suggesting that these metabolites share the same polyketide biosynthetic pathway.
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