Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 8, Pages 1366-1369Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np1001913
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Funding
- Office of the Higher Education Commission, Thailand
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Rajamangala University of Technology Isan
- Bioresources Research Network (BRN), National Center for Genetic Engineering and Biotechnology [BRN 001 G-49]
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Six new linear polyacetylenic C25 and C27 acetogenins (1-6), named debilisones A-F, have been isolated from a methanol extract of roots of Polyalthia debilis. Structures of these compounds were determined by spectroscopic techniques. The absolute configuration at C-17 of 2 was assigned by the modified Mosher's method. Compounds 2, 3, and 5 exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis with MIC values of 25.0, 12.5, and 25.0 mu g/mL, respectively.
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