Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 4, Pages 709-711Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9005184
Keywords
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Funding
- SENACYT, Panama
- NIH/NCI [T32CA009523-24]
- Fogarty International Center's International Cooperative Biodiversity Groups program [TW006634]
- NIH [CA52955]
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Fractionation of the extract of the marine cyanobacterium Lyngbya majuscula collected from Panama led to the isolation of malyngolide dimer (1). The planar structure of 1 was determined using ID and 2D NMR spectroscopy and HRESI-TOFMS. The absolute configuration was established by chemical degradation followed by chiral GC-MS analyses and comparisons with an authentic sample of malyngolide seco-acid (4). Compound 1 showed moderate in vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum (W2) (IC50 = 19 mu M) but roughly equivalent toxicity against H-460 human lung cell lines. Furthermore, because the closely related cyanobacterial natural product tanikolide dirtier (5) was a potent SIRT2 inhibitor, compound 1 was evaluated in this assay but found to be essentially inactive.
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