Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 5, Pages 915-919Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100067w
Keywords
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Funding
- NSFC [30830115, 20802082]
- Chinese Academy of Sciences [KSCX1-YW-R-24]
- 973 Program [2009CB522303, 2009CB522306, 2009CB940900]
- Scientific and Technological Projects of China [2009ZX09501-029]
- Young Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
- Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
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Twelve new dibenzocyclooctadiene lignans, marlignans A-L (1-12), together with 16 known compounds, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-12 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques. Compounds 1-12 were evaluated for their anti-HIV activities, of which compounds 3, 6, 8, and 12 showed modest activities with therapeutic index values of 13.2, 15.6, 17.6, and 16.4, respectively.
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