Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 7, Pages 1231-1236Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800694b
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Funding
- KMU-EM-97-2.l.a b
- National Science Council
- National Science Technology Program/Biotechnology and Pharmaceuticals, Taiwan
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Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.
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