Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 11, Pages 2076-2079Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9005597
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Funding
- NIH [U01 TW007404]
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The novel dienoyl tetramic acids tirandamycin C (1) and tirandamycin D (2) with activity against vancomycin-resistant Enterococcus faecalis were isolated from the marine environmental isolate Streptomyces sp. 307-9, which also produces the previously identified compounds tirandamycins A (3) and B (4). Spectroscopic analysis of 1 and 2 indicated structural similarity to 3 and 4, with differences only in the pattern of pendant oxygenation on the bicyclic ketal system. The isolation of these putative biosynthetic intermediates was enabled by their sequestration on an adsorbent resin during early stationary-phase fermentation.
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