Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 11, Pages 2053-2057Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900417g
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Funding
- BMBF
- MOST
- Official Medicines Control Laboratory (OMCL)
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Two new 10-oxo-10H-phenalenol[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids 1 (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneraria alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.
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