Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 5, Pages 894-899Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800751j
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Funding
- NIH [GM68944, 1R01GM0758556]
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Five new antibacterial ambiguine K-O isonitriles (1-5) and eight previously described indole alkaloids were isolated from the cultured cyanobacterium Fischerella ambigua (UTEX 1903) by bioassay-guided fractionation. The planar structures of the new compounds were determined by spectroscopic analysis including MS and 1D and 2D NMR. X-ray crystallography was used to determine the absolute stereoconfiguration of ambiguine K isonitrile. The isolates were evaluated for their antibacterial activities against a set of bacterial targets, including Mycobacterium tuberculosis and Bacillus anthracis. Ambiguine K and M isonitriles showed the most potent activity against M. tuberculosis, with MIC values of 6.6 and 7.5 mu M, respectively. Ambiguine A isonitrile showed the most potent activity against B. anthracis, with a MIC of 1.0 mu M.
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