Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 8, Pages 1471-1476Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900233c
Keywords
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Funding
- Recherche Cancer et Sang foundation, Televie
- Recherches Scientifiques Luxembourg (RSL)
- Action Lions Vaincre le Cancer
- Een Hderz fir kriibskrank Kanner
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Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J-L (1, 2, 6), and a new diterpene, 3'-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3-5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds wore tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.
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