Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 9, Pages 1627-1630Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900320e
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A new phenyldihydronaphthalene-type lignan, vitexdoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine B (2), four new phenylnaphthalene-type lignans, vitexdoins B-E (3-6), and four known lignan derivatives (7-10) were isolated from Vitex negundo seeds. Their structures were elucidated by detailed analyses of NMR, IR, and MS data. The ability of the isolates to prevent nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages in a concentration-dependent manner was also studied. Compounds 5, 6, and 9 were among the most potent NO production inhibitors, with IC50 values of 0.13, 0.15, and 0.11 mu M, respectively. The introduction of free hydroxy groups plays a vital role in the potency of these compounds.
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