Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 7, Pages 1283-1287Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9002433
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Funding
- Ministry of Health and Welfare for the Third-Term Comprehensive 10-Year Strategy for Cancer Control
- Ministry of Education, Culture, Sports, Science and Technology, Japan [16406002]
- Grants-in-Aid for Scientific Research [16406002] Funding Source: KAKEN
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A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC50 value of 9.3 mu g/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound I exhibited the most potent preferential cytotoxicity (PC50 4.3 mu M) in a concentration- and time-dependent manner. Furthermore, I induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.
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