Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 5, Pages 938-941Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800808h
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Funding
- Ministry of Education, Sports, and Culture of Japan.
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Two new daphnane diterpenoids, hirseins A (1) and B (2), were isolated from the aerial parts of Thymelaea hirsuta, and their structures were elucidated on the basis of spectroscopic data interpretation. Hirsein B (2) is an unusual daphnane in possessing a coumaroyl moiety. NOESY correlations of 2 implied that isomerization of the coumaroyl group in 2 was caused by equilibrium between the E (2e) and Z (2z) forms. Compounds 1 and 2 were found to inhibit melanogenesis in B16 murine melanoma cells.
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