Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 2, Pages 270-275Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8006793
Keywords
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Funding
- Ministry of Land, Transport, and Maritime Affairs, Korea
- Korea Institute of Marine Science & Technology Promotion (KIMST) [B10400207A290100900] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [핵06B3406, 과06A2601] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the course of our search for bioactive metabolites from a sponge-derived fungus Acremonium sp., new sesquiterpenoids (1-4) were isolated along with known derivatives by bioactivity-guided fractionation. The unique cyclic skeleton of compounds 2 and 3 is unprecedented. The absolute configurations were determined by modified Mosher's method and CD spectroscopy, along with comparison of H-1 and C-13 NMR spectroscopic data and specific optical rotation values with those reported. The anti-inflammatory activity of the isolated compounds (1, 5, 7-13) was evaluated by measuring their inhibitory effects on the production of pro-inflammatory mediators (NO, IL-6, and TNF-alpha) in RAW 264.7 murine macrophage cells. Among the compounds tested, compounds 7 and 9 significantly inhibited the production of NO and TNF-alpha at the concentration of 100 mu M, while compounds 11 and 12 showed selective inhibition of NO production at the same concentration.
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