Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 11, Pages 2058-2060Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900435d
Keywords
-
Funding
- MiUR
- Ente Cassa di Risparmio di Firenze, Italy
- CINMPIS
Ask authors/readers for more resources
Total synthesis of (-)-uniflorine A (3) has been accomplished in nine steps and 11% overall yield from carbohydrate-based nitrone 5. The key steps of the synthetic strategy were a high regio- and complete stereoselective 1,3-dipolar cycloaddition of alkene 6 with nitrone 5, a Tamao-Fleming reaction for replacing the silicon substituent with a hydroxy group with retention of configuration, and a Mitsunobu reaction to establish the correct configuration of the target molecule at C-6.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available