Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 6, Pages 1092-1096Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900021h
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Funding
- Ramkhamhaeng University
- Thailand Research Fund
- Royal Golden Jubilee Ph.D. Program
- Center for Innovation in Chemistry (PERCH-CIC), Commission on higher Education, Ministry of Education
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Eight new prenylated flavonoids, khonklonginols A-H (1-8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1-8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for anti mycobacterial activity against Mycobacterium tuberculosis H37Ra.
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