Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 1, Pages 14-17Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8003529
Keywords
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Funding
- International Cooperative Biodiversity Group (ICBG)
- Fogarty International Center's International Cooperative Biodiversity Groups (ICBG) [ICBG TWO06634]
- National Center on Minority Health and Health Disparities [5T37MDOO1480-13]
- SENACYT [EST06-0-022]
- FOGARTY INTERNATIONAL CENTER [U01TW006634] Funding Source: NIH RePORTER
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As part of a continuing program to identify novel treatments for neglected parasitic diseases, the Panama International Cooperative Biodiversity Group (ICBG) program has been investigating the antimalarial potential of secondary metabolites from Panamanian marine cyanobacteria. From over 60 strains of cyanobacteria evaluated in our biological screens, the organic extract of a Schizothrix species from a tropical reef near Piedras Gallinas (Caribbean coast of Panama) showed potent initial antimalarial activity against the W2 chloroquine-resistant strain of Plasmodium falciparum. Bioassay-guided fractionation followed by 2D NMR analysis afforded the planar structure of a new and highly functionalized linear peptide, gallinamide A. Subsequent degradation and derivatization methods were used to determine the absolute configuration at most stereogenic centers in this unusual new metabolite.
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