Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 6, Pages 1133-1141Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900123z
Keywords
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Funding
- NSFC [30830115, 20802082]
- Major State Basic Research Development Program of China [2009CB522303, 2009CB940900]
- Chinese Academy of Sciences [KSCX1-YW-R-24]
- Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
- Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
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Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC50 value of 7.9 mu M and a therapeutic index (TI) of more than 25.
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