Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 9, Pages 1651-1656Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900336f
Keywords
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Funding
- NIH [CA 36622]
- NSF [RR14768, RR06262, RR13030, DBI-0002806]
- Huntsman Cancer Institute
- University of Utah Seed
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Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Writ signaling and was subsequently shown to inhibit GSK-3 beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS3 spectra.
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