Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 9, Pages 1695-1698Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9002299
Keywords
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Funding
- Chinese National Natural Science Fund [30470196, 30670219]
- Chinese National High Technology Research and Development Program [2007AA091502]
- Chinese Academy of Sciences
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In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alteniaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 mu M..
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