Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 7, Pages 1253-1257Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900121m
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Funding
- National Cancer Institute-National Cooperative Drug Discovery Group [CA 67786]
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Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C5D5N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.
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