Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 12, Pages 2098-2103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900576b
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Funding
- University of Malaya (UMRG)
- MOHE Malaysia (FRGS)
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Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells.
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