Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 1, Pages 99-101Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8006843
Keywords
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Funding
- National High Technology Research and Development Program of China [2007AA09Z412]
- Chinese Academy of Sciences [KZCX2-YW-209, KZCX2-YW216]
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Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC50 of 6.7 mu g/mL.
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