4.7 Article

Alternaramide, a Cyclic Depsipeptide from the Marine-Derived Fungus Alternaria sp SF-5016

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 11, Pages 2065-2068

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np900464p

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Funding

  1. Korea Foundation for International Cooperation of Science & Technology (KICOS) [M60602000001-06E0200-00100]
  2. Korean Ministry of Education, Science & Technology (MEST)
  3. KRIBB Research Initiation Program

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Alternaramide (1), a cyclic pentadepsipeptide, has been isolated from an EtOAc extract of the marine-derived fungus Alternaria sp. SF-5016 by various chromatographic methods. The structure of I was mainly determined by analysis of the NMR spectroscopic data, along with chemical methods such as Marfey's and Mosher's methods. Alternaramide (1) showed weak antibiotic activity against Bacillus subtilis and Staphylococcus aureus.

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