Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 8, Pages 1373-1378Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8007792
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Four novel cyclic undecapeptides, lyngbyazothrins A (1), B (2), C (3), and D (4), were isolated from the cultured Lyngbya sp. 36.91 as binary mixtures (1/2 and 3/4). Their structures were elucidated by analysis of 1D (H-1 and C-13) and 2D (COSY, TOCSY, ROESY, NOESY, HMQC, and HMBC) NMR spectra, ESIMSMS, ESITOFMS, and amino acid analyses. Three unusual amino acids were present and identified as 4-methoxyhomophenylalanine in 1 and 3, homophenylalanine in 2 and 4, and 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid (Aound) in all compounds, while 3 and 4 have an additional N-acetyl-N-methyltyrosine unit. The mixture of lyngbyazothrins A (1) and B (2) shows only low antimicrobial activity against Micrococcus flavus, whereas the mixture of lyngbyazothrins C (3) and D (4) was active against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Serratia marcescens. It seems that the acyl residue at C-5 of the Aound unit plays an important role in antimicrobial activity.
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