Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 9, Pages 1579-1584Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800294q
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Funding
- the Bundesministerium fur Bildung and Forschung (BMBF) [03F0415A]
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Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new natural products chaetoxanthones A, B, and C (1-3). Compounds 1 and 2 are substituted with a dioxane/tetrahydropyran moiety rarely found in natural products. Compound 3 was identified as a chlorinated xanthone substituted with a tetrahydropyran ring. The configurational analysis of these compounds employed CD spectroscopy, modified Mosher's method, and selective NOE gradient measurements. Compound 2 showed selective activity against Plasmodium falciparum with an IC50 value of 0.5 mu g/mL without being cytotoxic toward cultured eukaryotic cells. Compound 3 displayed a moderate activity against Trypanosoma cruzi with an IC50 value of 1.5 mu g/mL.
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