Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 6, Pages 1011-1015Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800069u
Keywords
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Funding
- NIEHS NIH HHS [2 P42 ES04940-11] Funding Source: Medline
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Viscosin (1), an effective surface-active cyclic lipopeptide, was efficiently recovered from Pseudomonas libanensis M9-3 with a simple purification protocol. A major pigment also obtained during this process was identified as phenazine-1-carboxylic acid. The critical micelle concentration (cmc) of viscosin was determined to be 54 mg L-1, and the minimum surface tension between air and water at the cmc was 28 mN m(-1). Viscosin forms stable emulsions even at low concentrations (7.5 mg L-1), and the conditional stability constant for a cadmium - viscosin complex was determined to be 5.87. The physicochemical properties measured for viscosin are similar to other well-studied biosurfactants such as rhamnolipid and surfactin. Viscosin inhibited migration of the metastatic prostate cancer cell line, PC-3M, without visible toxicity. These properties suggest the potential of viscosin in environmental and biomedical applications.
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