Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 9, Pages 1630-1633Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800248s
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Funding
- the Bundesministerium for Bildung and Forschung [03170346A]
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2,5-Bis(hydroxymethyl)furan monoacetate (3) and 2,5 -bis(hydroxymethyl)furan diacetate (4) were obtained as new natural products from an ethyl acetate extract of the terrestrial Streptomyces sp. isolate GW11/1695. Another Streptomyces isolate. GW21/1313, delivered a dimer (6) and a trimer (7) of (hydroxymethyl)furfural. The latter strain also produced 4-hydroxy-2-(5 -(hydroxymethyl)furan-2-ylmethylene)-5-methylfuran-3-one (5), perlolyrin (8), and two new beta-carboline derivatives, 9 and 10. 2,5-Bis(hydroxymethyl)furan diacetate (4) exhibited weak cytotoxic activity against brine shrimp larvae.
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