Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 11, Pages 1970-1972Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800493p
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Funding
- NOAA OHHI [NA04OAR4600206]
- NSF [OCE 04-32479]
- NIEHS [ES P50 ES012740]
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In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this extract resulted in the isolation of a series of known and new prodiginine-type azafulvenes. The structure of the major metabolite was elucidated by interpretation of spectroscopic data as a 2-substituted prodigiosin, which we named 2-(p-hydroxybenzyl)prodigiosin (HBPG).
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