Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliatao

Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.