Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 11, Pages 1872-1876Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800380d
Keywords
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Funding
- Ministry of Education, Science, Sports, Culture and Technology of Japan
- Japan Society for the Promotion of Science
- Ministry of Health, Labour and Welfare
- Astellas Foundation for Research on Medicinal Resources
- Takeda Science Foundation
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Phytochemical investigation of leaves of Macaranga tanarius resulted in the isolation of seven new prenylated flavanones, macaflavanones A-G (1-7), along with two known compounds, nymphaeol C (9) and the diterpene kolavenol. The structures of the new compounds were elucidated by means of a combination of spectroscopic methods and chemical conversion. The absolute structure of tanariflavanone B (8), isolated from the title plant, was also resolved. The cytotoxic activities of isolated flavanones were assayed using two cell lines, with macaflavanone G (7) being the most active compound in each case.
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