Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 11, Pages 1911-1914Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800233q
Keywords
-
Funding
- National Natural Science Foundation of China [20806005]
- Yong Scholars Fund of Beijing University of Chemical Technology [QN0809]
Ask authors/readers for more resources
Sulforaphane (1), a glucosinolate-derived isothiocyanate found in the cruciferous vegetable broccoli, is considered an anticarcinogenic component. In the present study, the proliferation and apoptosis induction in human lung adenocarcinoma LTEP-A2 cells by 1 was investigated. Compound 1 caused G(2)/M-phase arrest (p < 0.05) and increase of apoptotic cell fraction (p < 0.05) in a time- and dose-dependent manner. Intraperitoneal injection of 1 significantly inhibited growth of LTEP-A2 xenografts in nude mice, and 9 days after tumor cell implantation with 100 mg/kg intraperitoneal injection of 1, the average tumor weights in 1-treated mice was >70% lower than that of the control mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available