Botryolides A-E, decarestrictine analogues from a fungicolous Botryotrichum sp (NRRL 38180)

Four new decarestrictine analogues (botryolides A-D; 1-4), a biosynthetically related gamma-lactone (botryolide E; 5), and the known compounds decarestrictine D (6) and sterigmatocystin have been isolated from cultures of a fungicolous isolate of Botryotrichum sp. (NRRL 38180). The structures of these compounds were determined by analysis of 2D NMR and ESIMS data. The relative configurations of 1-5 were established on the basis of NMR data and/or X-ray diffraction analysis, while the absolute configuration of 1 was assigned using the modified Mosher method.