Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 9, Pages 1595-1599Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8002222
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Funding
- the University of Canterbury
- the German Academic Exchange Service (DAAD)
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The use of an HPLC bioactivity profiling/microtiter plate technique in conjunction with capillary probe NMR instrumentation and access to appropriate databases effectively short-circuits conventional dereplication procedures, necessarily based on multimilligram extracts, to a single, more rapid submilligram operation. This approach to dereplication is illustrated using fungal or bacterial extracts that contain known compounds. In each case the dereplication steps were carried out on microgram quantities of extract and demonstrate the discriminating power of H-1 NMR spectroscopy as a definitive dereplication tool.
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