Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 12, Pages 2038-2040Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800291d
Keywords
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Funding
- Scientific Research (FRS-FNRS). [3452005]
- Liege and Louvain-la-Neuve.
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A secoiridoid aglycone with an atypical skeleton, named fagraldehyde (1), together with several known secoiridoids (gentiopicroside (2), sweroside (3), and swertiamarin (4)) were isolated from the bark and leaves of Fagraea fragrans collected in Cambodia. The conformations of 1 were evaluated on the basis of molecular modeling and NOESY correlations. A hypothetical biogenesis of fagraldehyde was proposed to explain the unusual skeleton. Compound 1 was weakly active in vitro against Plasmodium falciparum.
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