4.7 Article

Notoamides F-K, Prenylated Indole Alkaloids Isolated from a Marine-Derived Aspergillus sp.

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 12, Pages 2064-2067

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np800471y

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Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology of Japan [18032033, 19310140]
  2. Keimeikai Foundation
  3. Grants-in-Aid for Scientific Research [19310140, 18032033] Funding Source: KAKEN

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Six new prenylated indole alkaloids, named notoamides F-K (8-13), were isolated from a marine-derived Aspergillus sp. Their structures, including absolute configurations, were elucidated by spectroscopic methods. Notoamide I (11) showed weak cytotoxicity against HeLa cells with an IC(50) value of 21 mu g/mL.

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