Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 8, Pages 1472-1474Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8002113
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Funding
- Science and Technology Center, Academy of Scientific Research and Technology (ASRT) [HEL-113-33]
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Chemical investigation of the Red Sea sponge Pseudoceratina arabica has led to the isolation and identification of seven brominated compounds including two new bromotyramine derivatives, hydroxymoloka'iamine (2) and moloka'iakitamide (6). and a new brominated phenolic compound, ceratinophenol A (5), together with the known compounds moloka'iamine (1), ceratinamine (3), 5-bromo-2,3-dihydroxy-6-methoxybenzaldehyde (4), and psammaplysin-A (7). Biological evaluation of these metabolites indicated that moloka'iamine and moloka'iakitamide possess significant parasympatholytic effects on isolated rabbit heart and jejunum. This finding has important implications for further biological investigation of this class of compounds. Moreover. these compounds showed weak antibacterial and antifungal activities.
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