4.7 Article

Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 11, Pages 1837-1842

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np800303t

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Funding

  1. Chinese National Science Fund [30672527]
  2. Shandong Provincial Natural Science Fund [Z2006C13]
  3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences

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Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures and stereochemistry of the new compounds were elucidated by spectroscopic and chemical methods, and their cytotoxicities were evaluated against the HL-60 and A-549 cell lines.

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