Journal
JOURNAL OF NATURAL MEDICINES
Volume 73, Issue 1, Pages 252-256Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-018-1244-4
Keywords
Leonurus japonicus; Oleanane triterpenes; Cytotoxic activities; A549; HeLa
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Funding
- NSFC-Jiangxi Province [20161BAB204179]
- Fund of Jiangxi provincial education office [GJJ150407]
- Fund of Post Doctoral in Jiangxi [06292023]
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Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3-5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13M.
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