Journal
JOURNAL OF NATURAL MEDICINES
Volume 68, Issue 2, Pages 363-371Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-013-0810-z
Keywords
Rheum emodi rhizomes; Lecithin-cholesterol acyl transferase activity; Post heparin lipolytic activity; HMG-CoA reductase; Antidyslipidemic activity; Antioxidant
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Funding
- CSIR, New Delhi
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The aim of the present study was to evaluate the antidyslipidemic effect of ethanolic extract of Rheum emodi rhizomes and its constituents in Triton-WR-1339 and high-fat diet (HFD)-induced dyslipidemic rats. In preliminary screening, the ethanolic extract showed significant activity in Triton-treated rats. Bioassay-guided fractionation of the ethanolic extract resulted in the identification of four anthraquinone derivatives, viz. chrysophanol, emodin, chrysophanol 8-O-beta-d-glucopyranoside and emodin 8-O-beta-d-glucopyranoside as active constituents. All these compounds significantly reduced plasma lipid levels. The most active compound emodin showed significant lipid-lowering activity in the HFD-fed model. In addition, these compounds showed significant antioxidant activity. The effect of emodin on enzymes modulating lipid metabolism confirms and supports the efficiency of emodin as a potent antidyslipidemic agent.
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