Journal
JOURNAL OF NATURAL MEDICINES
Volume 68, Issue 1, Pages 215-219Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-013-0778-8
Keywords
beta-Carboline alkaloid; Sulfate; Marine sponge; Luffariella variabilis
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [22310138, 22406001]
- Naito Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Uehara Memorial Foundation
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Two new beta-carboline alkaloids, variabines A (1) and B (2), were isolated from the Indonesian marine sponge Luffariella variabilis. Their structures were elucidated from spectral data, and 1 was found to be a sulfonated derivative of 2. Although numerous beta-carboline alkaloids have been isolated from natural sources to date, 1 is the first beta-carboline derivative containing a sulfate group. Compound 2 inhibited chymotrypsin-like activity of the proteasome and Ubc13 (E2)-Uev1A interaction with IC50 values of 4 and 5 mu g/mL, respectively, whereas 1 had little effect on the activity or interaction.
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