Journal
JOURNAL OF NATURAL MEDICINES
Volume 63, Issue 3, Pages 355-359Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-009-0331-y
Keywords
Piperaceae; Betel; Piper betle; Hydroxychavicol; Allopurinol; Eugenol
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Funding
- Ministry of Education, Culture, Sports, Science and Technology
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The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.
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