Journal
JOURNAL OF NATURAL MEDICINES
Volume 64, Issue 2, Pages 121-125Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-009-0368-y
Keywords
2 '-Hydroxychalcone; Desmethylinfectocaryone; Chalcone; Cryptocarya konishii; Lauraceae; Cytotoxicity; Tyrosine kinase; P-388 cells
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Funding
- JSPS
- Meiji Pharmaceutical University Asia/Africa Centre for Drug Discovery Program, Japan
- Doctoral Research Grant
- Higher Education Bureau
- National Education Department of Republic Indonesia
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Two chalcone derivatives, 2'-hydroxychalcone (1) and desmethylinfectocaryone (2), together with five known phenolic compounds infectocaryone (3), cryptocaryone (4), kurzichalcolactone A (5), pinocembrin (6) and trans-N-feruloyltyramine (7), were isolated from the methanol extract of the wood of Cryptocarya konishii. The structures of the new compounds were determined based on the analysis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of compounds 1-7 showed that compounds 2-4 strongly inhibited the growth of murine leukemia P-388 cells, whereas compound 4 significantly inhibited the enzyme.
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