Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 13, Issue 10, Pages 6485-6498Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2013.7525
Keywords
Cell Membrane; Polymeric Nanoparticles; Surface Functionalization; Cellular Uptake; Receptor Mediated Process; Cell-Penetrating Peptide Mediated Process
Categories
Funding
- National Key Special Science Program [2009ZX10 004-311]
- National Key Program for Developing Basic Research [2010CB933903]
- National Natural Science Foundation of China [61271056, 11204033, 21205013, 61201033]
- Fundamental Research Funds for the Central Universities [CXLX12_0119]
Ask authors/readers for more resources
With the rapid development of biotechnology and nanomedicine, extensive research has focused on the investigations of delivering large-cargo molecules using nanoparticles through the cell membrane for disease diagnosis and treatment. Various inorganic and polymeric nanoparticles with optimized surface properties have been developed to carry these active cargo molecules such as organic molecules, oligonucleotides and proteins. Phagocytosis and pinocytosis have been suggested as the two major uptake mechanisms for nanoparticles to enter into cellular interior, but such mechanisms are still under debate. In order to enhance the efficiency of cellular uptake of nanoparticles and further understand the physiological process, it is important to investigate detailed interaction mechanisms between nanoparticles and cell membranes. Here, we will review the recent advances of the effect of nanoparticle properties (e. g., nanoparticle shape, size, charge, surface modification, etc.) on cellular uptake mechanisms. These will aid in the future design and development of nanoparticles with improved surface properties for drug and biomolecule delivery. Up to now, novel analytical techniques have been used to examine nanoparticle-cell membrane interactions, but their detailed uptake mechanisms and pathways still need more in-depth research. It is suggested that developing appropriate analytical techniques to study cellular uptake mechanisms of nanoparticles in real time is urgently desired.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available