Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 12, Issue 5, Pages 4051-4056Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2012.5858
Keywords
Anionic Polyurethane Nanoparticles; Characterization; Blood Compatibility; Cell Cytotoxicity
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Funding
- NSFC [21144002]
- Natural Science Foundation of Jiangsu Province of China [BK2011781]
- RFDP [20103207120005]
- Nature Science Foundation of Jiangsu Higher Education Institutions of China [11KJB150009]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Base of Production, Education & Research of Prospective Joint Research Project of Jiangsu Province [BY2011109]
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The anionic polyurethane nanoparticles (APU-NPs) were obtained by an emulsion polymerization method. It was found that the average size of the prepared APU-NPs is about 84 nm, and the APU-NPs have zeta-potential of -38.9 mV. The bulk characterization of synthesized APU-NPs was investigated by FTIR. The blood compatibility of APU-NPs was characterized by in vitro for coagulation tests, complement activation, platelet activation, cytotoxicity experiments, and hemolysis assay. The results showed that the APU-NPs synthesized in this paper are blood compatible with low level of cell cytotoxicity, and the results were significant for their potential use in vivo.
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